Abstract
A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2 H is reported for the first time. This method enables direct and facile access to CF2 H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2 H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CF2 H bonds.
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