Abstract
A catalytic method for the trifluoromethylalkynylation of unactivated alkenes is presented. The reaction is catalyzed by silver(I) trifluoroacetate for the simultaneous construction of two C-C bonds (alkyl-alkyne and alkyl-CF3). By employing versatile hypervalent iodine reagents, ethynylbenziodoxolones, useful trifluoromethylalkynylated compounds can be prepared from simple alkenes displaying excellent functional group tolerability. A radical mechanism is proposed with supporting evidence, providing a new entry to silver(I)-catalyzed trifluoromethylation reactions.
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