Abstract
Microbes generally develop resistance towards organic antibacterial agents like ampicillin, Sulfonamides, methicillin, etc., and progressively new drugs are being invented to replace them. Hence, replacement of organic antibacterial agents with inorganic analogues requires constant research and the present investigation reports alternatives for conventional antimicrobial agents like methylparaben, diazolidinyl urea, etc., in the cosmetic products with silver incorporated calcium borates. The chemically synthesized silver-calcium borates have been analyzed for phase purity using powder XRD analysis, nature of bonding using FTIR vibrations, and morphology using SEM. The antibacterial and antifungal studies were carried out for the novel inorganic silver-calcium borates incorporated cosmetic products. The products were also subjected to thermal & photostability studies and found to be comparable with that of commercially available products. A minimum quantity of 3 ppm of silver-calcium borate concentration was required to bring about nearly 100% bacterial reduction in the cosmetic products.
Highlights
The health care and cosmetic products incorporated with antimicrobial and antiviral agents play a lead role in preventing spreading of infectious disease, especially in pandemic situations
An attempt to replace these antimicrobials with silver-calcium borates has been made
The FTIR spectra of Ag-CaB samples showed the presence of BO3 groups of borates resulting in B-O bending vibration at around 710 cm-1 and B-O stretching vibration at around 1330 cm-1 (Fig. 2)[16]
Summary
The health care and cosmetic products incorporated with antimicrobial and antiviral agents play a lead role in preventing spreading of infectious disease, especially in pandemic situations. The bactericidal effect of silver/cellulose bio-composite was analysed against multidrug-resistant strains and Generally, cosmetic products contain organic antimicrobials like triclosan in hand-wash, diazolidinyl urea in bodywash, and methylparaben in face cream[13]. Calcium borates are highly stable, non-reactive and insoluble in both aqueous and organic solvents and none of their components were reported to be carcinogenic according to IARC, ACGIH, NTP and OSHA. They possess very low antimicrobial effects, and their antimicrobial ability can be enhanced many folds by adding silver into the calcium borate matrix[14]. Three different cosmetic products such as body-wash, hand-wash and face-cream were short-listed to evaluate their antimicrobial performance, thermal stability and photo-stability
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