Abstract
The use of chemical devices for periodontitis treatment has led to new strategies aiming primarily to control infections. Over the last few years, new chemical devices have been subjected to many scientific and medical studies. The purpose of the present study was to assess the effect of a new silver based chemical devices gel named “Hydrosilver Plus Gel”, abbreviated here as Hydrosilver, on the pathogenic microorganisms, using Polymerase Chain Reaction (PCR) for microbiological analysis. Materials and methods: Ten patients with a diagnosis of chronic periodontitis in the age group >25 years were selected. None of these patients had received any surgical or non-surgical periodontal therapy, and demonstrated radiographic evidence of moderate bone loss. After scaling and root planning, patients received Hydrosilver to be used at home. Four non-adjacent sites in separate quadrants were selected in each patient for monitoring, based on criteria that the sites localise chronic periodontitis. Microbial analysis was analysed at baseline and at Day 15. SPSS program was used for statistical purposes and a paired samples correlation was performed at the end of the observation period. Results: Mean amounts of bacterial loading before and after Hydrosilver treatment reduced statistically significantly (p = 0.002). Conclusions: The present study demonstrated that Hydrosilver has a good impact on oral biofilm. Additional studies are needed to detect the efficacy of this chemical device.
Highlights
Periodontal disease (PD) is supposed to be the leading cause of tooth loss in the adult population [1]
The aim of this study was to assess the effect of a new oral gel named “Hydrosilver Plus Gel”, abbreviated here as Hydrosilver, on oral bacterial loading using Polymerase Chain Reaction (PCR)
PD affects about the 50% of adults or more, while; the severe periodontitis form affects around 10%
Summary
Periodontal disease (PD) is supposed to be the leading cause of tooth loss in the adult population [1]. PD is an inflammatory disease characterised by the formation of pathogenic microorganisms (PMs) on both the tooth surfaces and gingival tissues. Materials 2018, 11, 1483 of PMs inhabit the oral cavity, of which 150–200 are found in most individuals and over 400 are found in the periodontal pocket [2]. Theses PMs involve quorum sensing (cell-to-cell communication), metabolic cooperation, and show ability to elude the host immune system causing a high resistance to antibiotics [3]. The rapid innate immune system of the oral epithelia, gingival crevicular fluid, and saliva form the first line of defence against colonisation by PMs, that can disrupt the membrane integrity, targeting the cytoplasmic elements, causing bacterial cell death. Oral microbiota help maintain the complex ecological homeostasis between the host and PMs in the oral environment [4]
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