Abstract
Purpose To investigate the characteristics of silicone oil (SO) emulsification after vitrectomy for rhegmatogenous retinal detachment and their possible correlations with clinical factors. Methods The first 2 mL of washing out fluid after SO removal was collected, and used for the measurement of the size and number of SO droplets using a Multisizer® 3 Coulter counter (Beckman Coulter, USA). The correlations between SO droplets and clinical factors were analyzed. Results A total of 38 patients (23 males, 15 females) who underwent primary PPV with SO injection for RRD and whose retina stayed attached for ≥3 months after SO removal were included in the study. The average number of oil droplets was 1.96 × 106 ± 3.95 × 106/mL (range 0.17 × 106 to 21.71 × 106/ml), and 80.8% (range 64.23%–99.07%) of the droplets were 1-2 μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all P > 0.05). When the emulsified SO droplets were divided into groups by their diameter, multiple linear regression revealed that age was negatively correlated with the numbers of 5–7-μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all P > 0.05). When the emulsified SO droplets were divided into groups by their diameter, multiple linear regression revealed that age was negatively correlated with the numbers of 5–7-μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all P > 0.05). When the emulsified SO droplets were divided into groups by their diameter, multiple linear regression revealed that age was negatively correlated with the numbers of 5–7-Conclusion Using a Multisizer® Coulter counter, we successfully determined the number and size of SO droplets after emulsification. We found that the number of 5–12-μm-diameter droplets was higher in younger-age patients and was higher in patients using antiglaucoma eyedrops.μm in diameter. The total number of emulsified SO droplets was not correlated with any clinical factor (all
Highlights
Silicone oil (SO) was first introduced into the field of ophthalmology by Cibis et al [1] in 1962
At the time of SO removal, 17 patients were using topical antiglaucoma medications, and in 7 of these patients, intraocular pressure (IOP) was higher than 21 mmHg
After SO removal, eight patients were still using antiglaucoma eye drops at their last visit, with IOP
Summary
Silicone oil (SO) was first introduced into the field of ophthalmology by Cibis et al [1] in 1962. SO has become an important tool for postoperative tamponade in complicated vitreoretinal cases. The problem of emulsification soon arose [2] and it became a concern for vitreoretinal surgeons. Emulsification was reported to be correlated with many complications, including glaucoma, [3] inflammation and proliferation, [4] cataract, [5], and keratopathy [6]. Emulsification was evaluated by using silt lamp or under a microscope, [7, 8] which are highly subjective methods and difficult to quantify. To explore the correlation between emulsification and these complications, a reliable method was needed to quantify the degree of SO emulsification. Chan et al [9, 10]
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