Silicon Nanoparticles: Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti‐Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections (Adv. Mater. 35/2017)

Abstract

In article number 1701527, Sangeeta N. Bhatia and co-workers engineer an antibacterial by fusing two peptide domains to target and kill bacteria and then encapsulate them in a biodegradable porous silicon nanoparticle. These nanomaterials kill bacteria and improve animal survival after treatment of a lung-infection model. This approach represents a new strategy for the development of antibacterials to combat the rising incidence of antibiotic resistance in the clinic.