SILICA SUPPORTED PERCHLORIC ACID: AN EFFICIENT AND RECYCLABLE CATALYST FOR SYNTHESIS OF BENZIMIDAZOLO[2,3-b]QUINAZOLINONES

Vinod V Thorat,Sunil U Tekale,Maya V Katariya,Rupali L Magar,Samson Mashele,Rajendra P Pawar,Pravin S Kendrekar

doi:10.17628/ecb.2019.8.313-317

Abstract

Synthesis of benzimidazolo[2,3- b ]quinazolinone derivatives has been reported in excellent yields by using silica-supported perchloric acid (HClO 4 -SiO 2 ) as a mild and reusable heterogeneous catalyst. The procedure is simple, environmentally benign and has the advantage of high atom economy. Furthermore, the catalyst can be recovered and reused several times efficiently without substantial loss of catalytic activity.

Highlights

Heterogeneous catalysis is an interesting area of research from an industrial point of view
Synthesis of benzimidazolo[2,3-b]quinazolinone derivatives has been reported in excellent yields by using silica-supported perchloric acid (HClO4-SiO2) as a mild and reusable heterogeneous catalyst
In continuation of previous studies on silica-supported perchloric acid19-21 we developed an efficient and environment-friendly method for the synthesis of quinazolinone derivatives by the condensation of substituted aldehydes, 2-aminobenzimidazole, and dimedone using silica-supported perchloric acid as a heterogeneous catalyst (Scheme 1)

Summary

Introduction

Heterogeneous catalysis is an interesting area of research from an industrial point of view. Synthesis of benzimidazolo[2,3-b]quinazolinone derivatives has been reported in excellent yields by using silica-supported perchloric acid (HClO4-SiO2) as a mild and reusable heterogeneous catalyst. In continuation of previous studies on silica-supported perchloric acid19-21 we developed an efficient and environment-friendly method for the synthesis of quinazolinone derivatives by the condensation of substituted aldehydes, 2-aminobenzimidazole, and dimedone using silica-supported perchloric acid as a heterogeneous catalyst (Scheme 1).

Results

Conclusion