Abstract
Convenient and sensitive detection of active analytes in complex matrix is crucial in biological, medical, and environmental analysis. Silica nanochannel array film (SNF) equipped electrochemical sensors have shown excellent anti-fouling performance in direct analysis of complex samples. In this work, we demonstrated an electrochemical sensor with anti-fouling performance for highly sensitive detection of acetaminophen (APAP) based on SNF supported by ß-cyclodextrin-graphene (CDG) nanocomposite modified Au film electrode (AuF). Because of their rich surface hydroxyls and 2D lamellar structure, CDG on AuF can serve as the nanoadhesive for compact binding SNF, which can be grown by electrochemical assisted self-assembly method in a few seconds. Attributable to the electrocatalytic property of graphene and the synergistic enrichment from both CD and SNF nanochannels towards analyte, the SNF/CDG/AuF sensor demonstrates sensitive detection of acetaminophen ranged from 0.2 to 50 μM with an ultralow limit-of-detection of 14 nM. Taking advantage of the anti-fouling ability of SNF, the sensor is able to realize accurate and convenient analysis of APAP in commercially available paracetamol tablets.
Highlights
Electrochemical sensors have attracted much attention owing to their high sensitivity, simple operation, and no need of expensive instruments (Bollella et al, 2017; Cesewski and Johnson, 2020; Bagheri et al, 2021; Mehmandoust et al, 2021; Min et al, 2021; Karimi-Maleh et al, 2022)
We demonstrate the integration of Silica nanochannel array film (SNF) with ß-cyclodextrin-graphene (CDG) nanocomposite modified Au film electrode (AuF) for sensitive and direct electroanalysis of acetaminophen, an antipyretic analgesic
At the same time, -OH groups in both CD and reduced graphene oxide (rGO) facilitate the stable binding of SNF through forming hydrogen bond or covalent Si-O-C bonds
Summary
Electrochemical sensors have attracted much attention owing to their high sensitivity, simple operation, and no need of expensive instruments (Bollella et al, 2017; Cesewski and Johnson, 2020; Bagheri et al, 2021; Mehmandoust et al, 2021; Min et al, 2021; Karimi-Maleh et al, 2022). Direct electrochemical analysis of complex samples is challenging because of anti-fouling or anti-interference from the complicated matrix (Yan et al, 2016; Lu et al, 2018). Silica nanochannel array film (SNF) has been proven to be an effective anti-fouling and anti-inference layer to functionalize the supporting electrodes. SNF is an ultrathin nanofilm with highly uniform and Modified Gold Film Electrode Sensor high density nanochannels perpendicular to the supporting electrode (Poltorak et al, 2013; Ma et al, 2020; Ding et al, 2021; Ullah et al, 2021; Yan et al, 2021). Most biological macromolecules or other large substances in complex samples have difficulties in entering the ultrasmall nanochannels of SNF, providing outstanding anti-fouling ability. SNF modified electrode has great potential in direct and sensitive electroanalysis of complex samples
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