Abstract
Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.
Highlights
Studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported
Mesoporous silica is intensively studied as carrier in drug delivery systems (DDS) for its outstanding properties: high specific surface area and total pore volume providing a good loading capacity of biologically active molecules, an ordered pore framework with narrow pore size distribution useful in sustained drug release and the possibility to modify the silica surface properties through functionalization in order to tailor the interactions between the support and guest molecules for desired drug delivery kinetics [4-6]
This was proved in a study focused on the development of ketoprofen delivery systems based on pristine and 3 aminopropyl functionalized SBA-15 mesoporous silica
Summary
Tetraethylorthosilicate (TEOS, Fluka), 3-aminopropyl triethoxysilane (98%, Aldrich), hexadecyltrimethyl-ammonium bromide (CTAB, Fluka), ammonia aqueous solution 25% (Scharlau), hydrochloric acid 36.5-38% (Sigma), 1,3,5trimethylbenzene (TMB, Sigma-Aldrich), poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), EO20PO70EO20 (Pluronic P123, average molecular weight 5800, Sigma-Aldrich), toluene (Sigma-Aldrich), ammonium nitrate (≥ 98%, Sigma-Aldrich) and ketoprofen (≥ 98%, Sigma) were used as received without further purification. Into 20 mL sodium alginate aqueous solution (2% wt), 0.1 g ketoprofen-loaded silica were slowly added under magnetic stirring (600 rpm), at room temperature for 0.5 h, to obtain a homogeneous suspension. The resulted beads were allowed to cure into the gelation medium for 30 minutes and they were three times washed with acidic aqueous solution, separated by decantation and dried in air, at room temperature. The drug content in ketoprofen-silica-alginate beads was determined by UV-vis spectroscopy (Shimadzu UV1800 spectrometer) computed as difference between the initial amount of ketoprofen-loaded into the silica support and the quantity of therapeutic agent lost in calcium chloride solution after the beads formation and in washing waters. Materials characterization The carriers and ketoprofen-loaded mesoporous silica were investigated through: small- and wide-angle X-ray diffraction (XRD), FTIR spectroscopy and N2 adsorptiondesorption isotherms. REV.CHIM.(Bucharest)♦69♦No 12 ♦2018 ketoprofen-silica alginate beads were characterized by thermal analysis (DTA-TG) performed in the same conditions as for functionalized silica supports and by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDX) using Tescan Vega 3 LM electron microscope
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