Abstract
Aim: In the current study, efforts are being made to prepare Inhalable Silibinin loaded solid lipid nanoparticles (SLNs) with narrow size distribution with improved bioavailability. Methods: SLNs were formulated by high shear homogenization method SLNs were characterized, including Differential Scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), particle size analysis, entrapment efficiency with Aerodynamic behaviour.. The MTT assay was performed against A549 cell line, to measure their anticancer cell activity with Invio study. Results: Optimized formulation exhibited spherical surface with a mean particle size of 221 ± 1.251 nm, PI of 0.121 ± 0.081, zeta potential of -4.12 ± 0.744. Aerodynamic behaviour such as Mass median aerodynamic diameter (MMAD) and Geometric size distribution (GSD) were found to be 5.487 ± 0.072 and 2.321 ± 0.141 respectively proved formulation is suitable for inhalation. In vitro cellular efficacy against A549 cells, revealed that the optimized formulations were more effective and potent Conclusion: The Inhalable SLNs approach was successfully engineered and administered to the lungs safely without causing any problems.
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