Abstract
BackgroundPatients with impaired glucose tolerance (IGT) have an increased risk of cardiovascular disease (CVD) that is independent of traditional risk factors. Hence, slightly elevated glucose levels, even in the non-diabetic range, might be associated with increased macrovascular disease.MethodsWithin the Northern Sweden MONICA project a population survey was performed in 1986. Electrocardiograms (ECG's) were recorded for half of the survey (n = 790) and oral glucose test was carried out in 78 % of those. The association between subjects with ECG's indicating previously unknown myocardial infarction (ukMI), IGT and conventional risk factors were analyzed by logistic regression for men and women separately, adjusting for age, smoking, hypercholesterolemia and hypertension.ResultsImpaired glucose tolerance was significantly more common among women with ukMI, but not in men, compared to the group with normal ECG. In men, no variable was significantly associated with ukMI although the odds ratio (OR) for hypercholesterolemia was of borderline significance, 3.2 (95% confidence interval (CI) 0.9 to 11). The OR of having ukMI was 4.1 (CI 1.1 to 15) in women with IGT compared to women with normal glucose tolerance after multiple adjustment. The OR for hypertension was of borderline significance; 3.3 (CI 0.97 to 11).ConclusionWe found that IGT was associated with ECG findings indicating silent myocardial infarction in women in a middle-aged general population in northern Sweden. The results persisted even after adjusting for known risk factors.
Highlights
Patients with impaired glucose tolerance (IGT) have an increased risk of cardiovascular disease (CVD) that is independent of traditional risk factors
Patients with impaired glucose tolerance have an increased risk of CVD that is independent of traditional risk factors such as hypertension, smoking and hypercholesterolemia [4] and it has been suggested that slightly elevated glucose levels, even in the non-diabetic range, might
The results have indicated that ethnicity, sex and age might be factors that modify the strength of the risk of coronary heart disease (CHD) with impaired glucose tolerance [6,7,8,9,10,11]
Summary
Patients with impaired glucose tolerance (IGT) have an increased risk of cardiovascular disease (CVD) that is independent of traditional risk factors. Slightly elevated glucose levels, even in the non-diabetic range, might be associated with increased macrovascular disease. Diabetes contributes strongly to the risk of CVD with a risk that is increased four to six times, both for stroke and myocardial infarction [1]. Patients with impaired glucose tolerance have an increased risk of CVD that is independent of traditional risk factors such as hypertension, smoking and hypercholesterolemia [4] and it has been suggested that slightly elevated glucose levels, even in the non-diabetic range, might (page number not for citation purposes). The results have indicated that ethnicity, sex and age might be factors that modify the strength of the risk of CHD with impaired glucose tolerance [6,7,8,9,10,11]
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