Abstract
Purpose: The purpose of this study is to compare the aqueous humor level of Silent Information Regulator T1 (SIRT1) between patients with Age-related Macular Degeneration (AMD) and cataract patients. Materials and Methods: Aqueous humor level of SIRT1 was measured by enzyme-linked immunosorbent assay in 13 patients with wet-type AMD (n=13, AMD group) and 13 patients with cataracts (cataract group). In addition, the thickness of each retinal layer was determined by optical coherence tomography. Results: The aqueous humor level of SIRT1 was significantly lower in the AMD group than in the cataract group (p=0.007). In the AMD group, the SIRT1 level was positively correlated with the thickness of the retinal ganglion cell layer (r=0.31) and the inner nuclear layer (r=0.76). Conclusion: The aqueous level of SIRT1 decreased as the ganglion cell layer and inner nuclear layer became thinner, suggesting that reduction of SIRT1 activity might be involved in the pathogenesis of this disease.
Highlights
It has been suggested that sirtuins are involved in aging [1, 2]
The grades of cataract were grade 3-4 according to the Emery-Little classification of nuclear hardness
The present study demonstrated that the Silent Information Regulator T1 (SIRT1) level in aqueous humor was significantly lower in patients with Age-related Macular Degeneration (AMD) than in cataract patients with cataract
Summary
It has been suggested that sirtuins are involved in aging [1, 2]. Sirtuin overexpression prolongs the lifespan of various organisms, whereas sirtuin deletion or mutation shortens survival [3 - 5]. A total of seven sirtuin homologues designated as Silent Information Regulator T1 (SIRT1) to SIRT7 have been identified [6, 7]. SIRT1 deacetylates both histone and non-histone proteins to regulate gene transcription and protein function. It is an important anti-aging molecule with a role in preventing agerelated diseases induced by oxidative stress. Various studies have assessed the role of SIRT1 in the eye [8, 9], including its
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