Abstract
31.5 3mmHg compared to 15 1.7mmHg in controls. CO treated, hypoxic mice had mPAP of 21 3.1(P 0.05). eNOS protein increased in the CO treated hypoxic mice determined by immunohistochemistry. CO did not protect eNOS-/mice. mPAP in hypoxic eNOS-/mice was 24 1.1 compared to 14 2.1 in non-hypoxic controls, while CO treated hypoxic eNOS-/mice were 24 2.6. Furthermore, CO increased expression of eNOS in cultured PAEC.
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