Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells.

Abstract

Although some circRNAs have been found to regulate the progression of colorectal cancer (CRC). However, their functions have not been completely clarified. In the present study, a novel circRNA hsa_circ_0007534 was investigated in CRC tumor tissues and cell lines. The expression profile of circRNAs in CRC tumor tissues was performed by human circRNA microarray. The CCK-8 and apoptosis assay were measured in CRC cell lines after transfected with si-circRNA and si-NC. We analyzed a cohort of 33 patients with CRC and demonstrated that the expression of hsa_circ_0007534 was significantly up-regulated in CRC tumor tissues as compared to adjacent non-tumorous tissues. Moreover, hsa_circ_0007534 expression was correlated with tumor stage and lymph node metastasis. Furthermore, the silence of hsa_circ_0007534 by siRNA significantly inhibited proliferation and induced apoptosis of CRC cells. Hsa_circ_0007534 plays a crucial role in the initiation and progression of CRC and may be a potential therapeutic target of CRC.