Abstract
A series of novel sulfonamide-bridged silatranes 3,4,6,7 has been synthesized by the reaction of N,N-dichloroarylsulfonamides 1a-d with 1-vinylsilatrane 2 and 1-allylsilatrane 5. The structure of the silatrane-sulfonamide hybrids is characterized by elemental analysis, FT-IR, NMR (1H, 13C, 29Si and 15N) spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. The resulting hybrids 4a-d and 7a-d have been investigated by computational screening via ADMET and PASS. These compounds exhibit drug-like features, bioavailability and may have high enzyme-inhibitory activity. The screening (in vitro) of hybrids 4a,b,d and 7a,b for antimicrobial activities against pathogenic bacterial strains shows that these compounds possess antibacterial properties.
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