Abstract
Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K2CO3 / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
Highlights
The activity of a wide spectrum of heteroaromatic sulfides on the heart and blood circulatory system was described [1]
Indole sulfur derivatives were used in the treatment of atherosclerosis [44], arthritis [45, 46], diabetic complications [47] and congestive hearth failure [48]
Powdered dry K2CO3 was added to a mixture of 10 mmol of thiol (1 7), 10 mmol of 1-(3
Summary
The activity of a wide spectrum of heteroaromatic sulfides on the heart and blood circulatory system was described [1]. Quinoline sulfides exhibit antihypertensive [2,3,4], vasodilating [2,3], hypotensive [5, 6], euglicemic and hypolipidemic [7], antithrombotic [8], cardiotonic [9], cardiovascular [10-. Imidazole and benzimidazole sulfides exhibit vasodilating [22], antihypertensive [23], hypoglycemic [24], antithrombotic [25], cardiotonic [26, 27], cardiovascular [28], cholesterol [29,30,31] and blood sugar lowering [32], antidiabetic [33, 34] activities, increase high density lipoprotein cholesterol over lipid fractions [35] and were used in the treatment of atherosclerosis [36,37,38,39] and osteoarthritis [40]. Indole sulfur derivatives were used in the treatment of atherosclerosis [44], arthritis [45, 46], diabetic complications [47] and congestive hearth failure [48]
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