Abstract
The adrenal gland of Rana esculenta contains PAS + acidophilic cells, called Stilling cells, which are present, throughout the year, in frogs kept in captivity. After hypophysectomy these cells slowly turn into lipidic cells. This transformation can be reversed by administration of ACTH. In the normal frog, ACTH induces a fast and intense transformation of Stilling cells into lipidic cells which dedifferentiate into protidic chromophobe cells. When the treatment is short, the interrenal glands recover a normal structure, when the treatment is chronic, the Stilling cells do not reappear. These results suggest that the Stilling cell is a stage in the secretory cycle of the interrenal cell essential to the maintenance of the potentialities of the gland.
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