Significantly skewed memory CD8 + T cell subsets in HIV-1 infected infants during the first year of life

Abstract

HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7 +CD45RA + naive CD8 + T cells was significantly decreased, while the frequency of CCR7 −CD45RA − effector memory CD8 + T cells was increased, compared with the control cohorts. A larger population of CD8 + T cells in HIV-infected infants displayed a phenotype consistent with senescence. Differences in CD4 + T cell subset frequencies were less pronounced, and no significant differences were observed between exposed and unexposed HIV-uninfected infants. We concluded that the proportion of naive, memory, effector and senescent CD8 + T cells during the first year of life is significantly altered by HIV-1 infection.