Abstract
Aim This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. Results The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all P < 0.0001). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Conclusion Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.
Highlights
According to the WHO report, there are approximately 257 million people with chronic hepatitis B virus (HBV) infections in the world [1]
Impaired glucose regulation and diabetes mellitus mostly manifest as high postprandial glucose levels in plasma and are commonly associated with IR or islet β cell dysfunction or both in the general population. e characteristics of glucose metabolism, abnormal glucose metabolism due to IR or islet β cell dysfunction, the characteristics of islet β cell function as indicated by the homeostasis model assessment of β cell function (HOMAβ) value [18], and its risk factors in chronic hepatitis B (CHB) patients are unclear. is study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by HOMA-β value and its risk factors in CHB patients
110 patients with CHB were entered into the CHB group. 110 patients without hepatitis B virus, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection who were matched to the CHB group according to sex, age, and body mass index (BMI) under the same glucose metabolism status were entered into the non-HBV group. e study was approved by the ethics committee of the Public and Health Clinic Centre of Chengdu (PJ-K2019-019-01)
Summary
According to the WHO report, there are approximately 257 million people with chronic hepatitis B virus (HBV) infections in the world [1]. Is study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by HOMA-β value and its risk factors in CHB patients.
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