Abstract
Although testicular biopsy is mainly indicated in cases of azoospermia, the use of testicular sperm for ICSI has been proposed as a novel clinical approach for those couples who obtain poor reproductive results in ICSI cycles with ejaculated semen. Clinical results from a meta-analysis showed better newborn rates, but if they are achieved through improvement on embryo ploidy or non-genetic traits remains to be elucidated. It has been postulated that testicular sperm are of better quality due to the damage avoided during transport through the seminiferous tubules and the epididymis, which could be the cause of reduced embryo quality and failure of IVF treatments.
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