Abstract
Patients with celiac disease had significantly decreased bone mineral density even in patients with no gastrointestinal symptoms. Only few bone studies are available on pediatric patients with celiac disease. Forty-six patients underwent measurement of areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) before the initiation of gluten-free diet. Anthropometric, laboratory and DXA measurements at baseline and at sixth month of the treatment were compared. The frequency of low aBMD Z-score (≤-1SDS) in both or any site was found to be 78.2% in this study. Of 16 patients with an aBMD Z-score of <-2SDS five gained more than 1SDS, and one gained more than 2SDS. Nine of 20 patients with an aBMD Z-score of <-1SDS completely normalized. The results of the study showed that low BMD is common in children with celiac disease at the time of diagnosis and could improve in a short period of six months with a strict gluten-free diet and adequate supplementation of calcium and vitamin D.
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