SIGNIFICANT FACTORS ASSOCIATED WITH INSULIN-LIKE GROWTH FACTOR 1 AND ITS BINDING PROTEIN 3 IN COLORECTAL CANCER – MULTIPLE REGRESSION ANALYSIS

Abstract

Aim: the aim of our study was to investigate the association of insulin-like growth factor-1 and its binding protein 3 levels with CRC risk factors and symptoms by multiple regression analyzes. Methods: The IGF-1 laboratory test was performed using the ECLIA method. Serum insulin and glucose levels were assessed by oral glucose tolerance test (OGTT) in fasting state and after 120 minutes of glucose loading (40 g / 1 m2 of body surface). Multiple regression analysis performed to study the mutual impact of different parameters on outcome (IGF-1 and IGF BP3). Results: Finally, significant variables (factors) were left in the model having mutual effect on the outcome (IGF BP3 value). The linear multiple regression function took the following form: Hence these factors (each factor in parentheses indicates the nature of the correlation - direct or inverse): X1 - Sex (direct); X4 – Code of Surgery (inverse); X7 – other general pains/symptoms (inverse); X13 - Flatulence Gases (inverse); X14 - Diarrhea (direct); X20 – A course of chemotherapy or radiation therapy before surgery (inverse); X27 – HOMA-S (direct); X28 - HOMA-IR (inverse); X31 – creatinine (direct). Conclusion: Based on the results of current study we concluded that CRC is multifactorial and many significant factors are responsible for its development. One of possible mechanisms for its development is the changes insulin/IGF-1 signaling pathway with other significant biological and non-biological factors.