Abstract
Proteoglycans include decorin, which plays a major role in collagen fibrillogenesis, growth factor modulation and direct regulation of cellular growth. Decorin binds to multiple collagen types and other proteins such as transforming growth factor-β [1]. It is well known that chronic ultraviolet (UV) exposure substantially alters the biochemical composition and architecture of the skin [2]. Photoaged skin appears to be characterized by decreased decorin levels [3]. In this pilot study, we aimed for the first time to investigate the effect of short-term UVA1 as well as UVB exposures on the mRNA and protein expression of decorin in human skin.
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