Abstract
Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014–2016 (8%) was significantly lower than the frequency in 2005–2007 (41%), 2008–2010 (35%), and 2011–2013 (25%). This reduction was closely associated with changes in genotypes.
Highlights
Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide
Pertactin is believed to play a role in adherence to human epithelial cells [2]; B. pertussis isolates that lack pertactin production have been identified in several countries where acellular pertussis vaccines (ACVs) have been introduced [3,4,5,6,7]
We observed a significant decrease in pertactin-deficient isolates within the B. pertussis population in Japan, caused by a genotypic replacement from the pertactin-deficient MT186 strain to the pertactin-producing MT27 strain
Summary
Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. Recent studies have demonstrated that pertactin-deficient strains could colonize the respiratory tract more effectively than pertactin-producing strains in ACV-vaccinated mice [9,10]. Supporting these results, an epidemiologic study suggested that ACV-vaccinated persons are more susceptible to pertactin-deficient strains than to pertactin-producing strains [11].
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