Abstract
Mean platelet volume (MPV) and platelet size distribution width (PDW) are markers of platelet (PLT) size and variability in PLT size as well as PLT activation [ 1 Bath P.M. Butterworth R.J. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7: 157-161 Crossref PubMed Scopus (629) Google Scholar , 2 Chu S.G. Becker R.C. Berger P.B. et al. Mean platelet volume as a predictor of cardiovascular risk: a systemic review and meta-analysis. J Thromb Haemost. 2010; 8: 148-156 Crossref PubMed Scopus (715) Google Scholar , 3 Gasparyan A.Y. Ayvazyan L. Mikhailidis D.P. Kitas G.D. Mean platelet volume: a link between thrombosis and inflammation?. Curr Pharm Des. 2011; 17: 47-58 Crossref PubMed Scopus (891) Google Scholar ]. Reduced PLT count and increased MPV values have been reported in unruptured abdominal aortic aneurysms [ 4 Balduini C.L. Salvini M. Montani N. et al. Activation of the hemostatic process in patients with unruptured aortic aneurysm before and in the first week after surgical repair. Haematologica. 1997; 82: 581-583 PubMed Google Scholar , 5 Milne A.A. Adam D.J. Murphy W.G. Ruckley C.V. Effects of asymptomatic abdominal aortic aneurysm on the soluble coagulation system, platelet count and platelet activation. Eur J Vasc Endovasc Surg. 1999; 17: 434-437 Abstract Full Text PDF PubMed Scopus (23) Google Scholar ]. Others, however, have noted lower PLT indices (MPV and PDW) in patients with aortic aneurysm compared to age-matched controls [ [6] Ihara A. Matsumoto K. Kawamoto T. et al. Evaluation of platelet indexes in patients with aortic aneurysm. Pathophysiol Haemost Thromb. 2005; 34: 269-273 Crossref PubMed Scopus (13) Google Scholar ]. High-grade inflammation is associated with low MPV whereas low-grade inflammation is associated with high MPV; inflammation may play a role in pathogenesis of aneurysm formation and rupture [ [3] Gasparyan A.Y. Ayvazyan L. Mikhailidis D.P. Kitas G.D. Mean platelet volume: a link between thrombosis and inflammation?. Curr Pharm Des. 2011; 17: 47-58 Crossref PubMed Scopus (891) Google Scholar ]. We studied PLT indices in patients with acute aortic dissection (AAD), chronic aortic aneurysms and age and sex matched normal subjects.
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