Abstract
Several studies have investigated a potential association between the endothelial lipase gene (LIPG) 584C/T polymorphism and susceptibility to coronary artery disease (CAD), but a uniform conclusion is yet to be reached. To better evaluate the true relationship between the LIPG 584C/T polymorphism and the risk of CAD, a meta-analysis of 14 case–control studies with 9731 subjects was performed. Relevant articles published through August 2020 were searched in the CNKI, PubMed, Embase and Web of Science databases. Thirteen articles, including 14 eligible case–control studies with 4025 cases and 5706 controls, were enrolled in the present meta-analysis. The Newcastle–Ottawa Scale (NOS) scores of the case–control studies ranged from 6 to 8. The pooled results indicated that there is a significant association between the LIPG 584C/T polymorphism and CAD in the homozygote comparison model and the allelic comparison model. Subgroup analyses revealed that the LIPG 584C/T mutation significantly decreased the risk of CAD in the subgroups of African, CAD, hospital-based (HB), and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) populations in some genetic models. No publication bias was found in our meta-analysis, which certifies the robustness of the current meta-analysis. Trial sequential analysis (TSA) also confirmed the stability of our results. The results of our meta-analysis indicate that the LIPG 584C/T polymorphism plays a protective role in the incidence of CAD. More high-quality case–control studies on various ethnicities are needed to confirm our results.
Highlights
Coronary artery disease (CAD), called coronary heart disease (CHD), characterized by myocardial hypoxia and ischemia is triggered by coronary atherosclerosis [1]
The integrated results indicated that the lipase gene (LIPG) 584C/T variation was significantly associated with CAD risk in the homozygote comparison model (TT vs. CC: odds ratio (OR) = 0.74, 95% confidence interval (CI) = 0.56–0.99, P=0.041, Pheterogeneity=0.029, Table 3 and Figure 2) and allelic comparison model (T vs. C: OR = 0.87, 95% CI = 0.76–0.99, P=0.037, Pheterogeneity=0.000, Table 3 and Figure 3)
In the subgroup analysis stratified by type of diseases, the results indicated that the LIPG 584C/T polymorphism was significantly associated with decreased CAD risk in the subgroup of CAD in three genetic models (TT vs. CC: OR = 0.55, 95% CI = 0.34–0.88, P=0.014; TT vs. CT + CC: OR = 0.66, 95% CI = 0.49–0.89, P=0.006; and T vs. C: OR = 0.79, 95% CI = 0.62–0.99, P=0.043), and the same results were shown in the HB group (TT vs. CC: OR = 0.48, 95% CI = 0.26–0.88, P=0.018) and PCR-RFLP (TT vs. CC: OR = 0.42, 95% CI = 0.25–0.70, P=0.001)
Summary
Coronary artery disease (CAD), called coronary heart disease (CHD), characterized by myocardial hypoxia and ischemia is triggered by coronary atherosclerosis [1]. It is a medical problem of human society and one of the leading causes of disability and deaths in every country [2,3]. The pathogenesis of CAD involves many risk factors, including hereditary and environmental factors. Many genetic variants have been identified to be related to the risk of CAD by previous genetic association studies [4]. Some SNPs may be related to the occurrence and development of CAD, while others are not [5,6]
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