Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease : A meta-analysis in the Chinese population.

Abstract

Agrowing number of studies have suggested that the single nucleotide polymorphism (SNP) rs662 (G>A) in paraoxonase1 (PON1) is significantly associated with susceptibility to coronary heart disease (CHD) in the Chinese population. To further evaluate the effects of the PON1 RS662 (G>A) polymorphism on the risk of CHD, we performed ameta-analysis in aChinese population. PubMed, Embase, Wanfang Data, Chinese National Knowledge Infrastructure (CNKI) were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations between RS662 (G>A) and CHD. In the meta-analysis, we identified 14articles, including atotal of 4835CHD patients and 5111controls in the Chinese population. Our result showed that overall rs662 (G>A) was significantly associated with susceptibility to CHD in the Chinese population when compared with healthy controls. Furthermore, aGallele suggested an elevated risk of CHD. In the subgroup analyses stratified by ethnicity and geographic areas, significant associations were found in Chinese Han and South China, but not in North China. The present meta-analysis suggests that rs662 (G>A) SNP in PON1 is associated with CHD risk; the Gallele might be the risk allele for CHD susceptibility in the Chinese population. However, more research is required to make adefinite conclusion.