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Abstract
Background: Maternal and perinatal morbidities are well-documented complications of pregnancy in women with thyroid dysfunction, both clinical and subclinical. About 2–5% of pregnant women suffer from thyroid disorders and timely intervention can be done if detected early. The presence of anti-TPO Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, pregnancy-induced hypertension, intrauterine death and low birth weight.
 Objectives: Study the effect of anti-TPO Ab positivity on pregnancy outcome especially birth weight and estimate the prevalence of anti-TPO Ab in euthyroid pregnant women.
 Methods: This observational study enrolled 500 euthyroid pregnant women, age 20-35 years, up to 20 weeks gestation. Venous blood samples collected and analyzed for the anti-TPO Ab levels. On the basis of Ab positivity they were divided into anti-TPO Ab positive and Ab negative group. These two groups were followed up till delivery and compared fetal outcomes for birth weight.
 Result: Prevalence of anti-TPO Ab positivity was 5.2% in euthyroid obstetric women. Most of anti-TPO Ab positive women were overweight. Incidence of low birth weight babies was 4 fold higher in anti-TPO Ab positive women.
 Conclusion: Anti-TPO Ab positivity significantly associated with prepregnancy BMI and low birth weight of newborns.
 Keywords: Thyroid peroxidase antibodies, Anti-TPO Ab, Euthyroid, Low birth weight.
Highlights
Pregnancy may serve as a glimpse into a woman’s future health because gestation presents many challenges for various organ systems
Anti-TPO Ab positivity significantly associated with prepregnancy body mass index (BMI) and low birth weight of newborns
The presence of TPO-Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, PIH, intrauterine death (IUD), intrauterine growth retardation (IUGR) and low birth weight babies.[6]
Summary
Pregnancy may serve as a glimpse into a woman’s future health because gestation presents many challenges for various organ systems. The presence of TPO-Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, PIH, intrauterine death (IUD), intrauterine growth retardation (IUGR) and low birth weight babies.[6] So, antiTPO Ab screening test can be an important routine diagnostic tool in early pregnancy which can help to identify women at risk for poor fetal outcome and pregnancy complications. The presence of anti-TPO Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, pregnancy-induced hypertension, intrauterine death and low birth weight. Objectives: Study the effect of anti-TPO Ab positivity on pregnancy outcome especially birth weight and estimate the prevalence of anti-TPO Ab in euthyroid pregnant women.
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