Abstract
In India, GI tract cancer is one of the ten leading cancers. Among Indian males it stands second to oral cancer and in females, it shares the third place. Most common malignant disorder of GIT is seen in our country that of liver, bile, gall bladder, pancreas, bileduct and colorectal. Aim: To see the significance of tumour markers in gall bladder cancer. Materials and Methods:This study comprise 225 cases of GI tract cancers was carried for more than two years. Of these, 22 subjects had gallbladder cancer. Tumour markers viz. CA19-9, CEA and AFP were assayed pre and post-operative cases and their role in gallbladder cancer was evaluated. Results: It was observed that serum concentration of CA 19-9 increased with advancing stage, but the same is not true for AFP and CEA. Sensitivity of these markers AFP, CA 19-9 and CEA in the detection of gall bladder cancer was determined. CA 19-9 is the most sensitive of all the three tumour markers in the detection of gall bladder cancer. Conclusion: The combination of CA19-9 and CT (or US) is a reasonable, cost-effective, noninvasive approach to establishing the diagnosis of pancreatic, cholangitic, or biliary cancer in nonicteric patients.
Highlights
Today, cancer is a vast medical problem
In India, GI tract cancer is one of the ten leading cancers; among males it stands second to oral cancer, while in females it shares the third place along with oral cavity cancer, the first two being cervix and breast cancer
Microparticle Enzyme Immunoassay (MEIA) method on Abbotts Axsym analyzer was used for this study. 5 ml of patients serum was collected and quantitative determination of each sample was done
Summary
It stands second only to cardiovascular diseases. In India, GI tract cancer is one of the ten leading cancers; among males it stands second to oral cancer, while in females it shares the third place along with oral cavity cancer, the first two being cervix and breast cancer. Most common malignant disorder of GIT is seen in our country that of liver, bile, gall bladder, pancreas, bileduct and colorectal. Prominent incidences, geographic variability and their correlation with prevalence of choleithiasis and Gall Bladder Cancer (GBC) have been reported. High rates of GBC was seen in South American countries, Chile, Bolivia, and Ecuador, as well as some areas of India, Pakistan, Japan and Korea [1,2]
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