Abstract
Total kininogen plus kinin activity was estimated in fluids collected from different types of rat paw oedema and also under conditions of pretreatment with either cyproheptadine or phenylbutazone. Elevated activity was found when serotonin or kaolin were used as subplantar irritants, but not when polyvinylpyrrolidone served as the oedema inducer. Rat paw oedema is thus not necessarily associated with the kinin system. Cyproheptadine reduced the total kinin activity and paw swelling induced by serotonin but not by kaolin. Phenylbutazone reduced both parameters with kaolin as the oedema producer, but failed to have any effect with serotonin as irritant. Although the two drugs are known to antagonize some effects of kinin, in this study they interfered, each in a different way, with production of either kininogen or kinin.
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