Significance of the expression of HMGB-1 and Tiam1 in non-small cell lung cancer tissues

Abstract

Objective To study the significance of the expression of high mobility group box-1 (HMGB-1) and T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small cell lung cancer tissues.Methods Fifty-one cases of non-small cell lung cancer were chose as the research objects.Cancerous tissues were enrolled into the observation group and adjacent tissues as the control group.Tissue HMGB-1 and Tiam1 expression levels were determined by immunohistochemical staining.Results HMGB-1 was mainly expressed in the nucleus and cytoplasm of cancer cells,stromal cells nucleus and cytoplasm,showed pale yellow to brown color.The positive expression in the observation group was 70.1％ (36/51),and in the control group was 7.8％ (4/51),there was significant difference between the two groups (x2 =9.27,P ＜ 0.05).Tiam1 positive staining was in the cytoplasm and cell membrane,showed yellow,brown or tan color,the positive expression of Tiam1 in the observation group was 66.7％ (34/51),the positive expression in the control group was 5.9％ (3/51),there was significant difference between the two groups (x2 =10.36,P ＜ 0.05).The lung tissue HMGB-1 and Tiam1 expression levels were not correlated with gender,histological type,tumor differentiation degree (P ＞ 0.05),but were closely related with TNM stage,lymph node metastasis,recurrence (P ＜ 0.05).Conclusions HMGB-1 and Tiam1 expression levels in non-small cell lung cancer were high,and they can predict the prognosis of patients. Key words: Non-small cell lung cancer; High mobility group box-1 (HMGB-1) ; T-cell lymphoma invasion and metastasis 1 (Tiam1)