Significance of the composition of conduit internal environment for the activation of axon growth in patients with extended peripheral nerve defects

Abstract

The recovery of peripheral nerves after injury is an urgent medical problem. Despite the advances in microsurgery techniques, it is still not possible to achieve complete holistic and functional recovery. It is more difficult to repair neural tissue after injury if there is a diastasis between the injured ends nerves. In this case, neurorraphy can not be carried out due to the eruption of the filaments in tension and convergence of proximal and distal ends of the axon. Modern tactics of restoration of extended defects of nerves involves the use of conduits - cylindrical conductors, overlapping posttraumatic diastasis, in order to create a vector of regeneration from the proximal part of the nerve to the distal. An ideal conduit should contain an internal environment that stimulates the recovery processes of nerve fibers. At present, there is no unified approach involving the use of a certain natural or artificial conduit environment. The review analyzes the regenerative potential of the internal environments of conduits as the most promising in modern biotechnologies for the reconstruction of extended peripheral nerve defects.