Abstract
ConclusionsMale mice of strain D treated with estrogen after sexual maturity developed leukemia more readily than those injected from an earlier age on. In castrated males, the incidence of estrogen induced Leukemia was significantly increased over that in non-castrated animals, if the treatment was started at an early age. In females receiving estrogen from an early age on, ovariectomy slightly decreased the incidence of leukemia, and in those treated after sexual maturity, no effect of ovariectomy was noted.
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