Abstract
The expression of senescence marker protein‐30 (SMP30) was discovered by proteomic analysis. The fact that this molecule's structure is so highly conserved among numerous species strongly suggests that the age‐dependent decrease of SMP30 may contribute to senescence. Research that targeted the SMP30 gene showed deterioration in several organs accompanied by a shortened life span. We then identified SMP30 as gluconolactonase (GNL). The lactonase reaction with L‐gulono‐γ‐lactone is the penultimate step in vitamin C (L‐ascorbic acid) biosynthesis. Our discovery has opened the door to a new aspect of aging studies.
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