Abstract
Significance of REM Sleep in Depression: Effects on Neurogenesis
Highlights
REM deregulations have been described to have a role in the production of the core symptoms of mood disorder contributing to the core features of cognitive distortion including self-worth [7] and to negative emotional memories consolidation
Studies have demonstrated that there is a failure of sleep dependent emotional brain processing in REM sleep in depression which seems to support the development of clinical depression [8]
The “Monoamine Hypothesis,”ACh-hypersensitivity” in depression indicate a key role of REM sleep dysregualtions as specific features of this disorder due to cholinergic hyperactivity [14] which might be under genetic control
Summary
Disturbances of sleep are typical of depression and are observed in between 50% and 90% of depressed subjects [1]. REM deregulations have been described to have a role in the production of the core symptoms of mood disorder contributing to the core features of cognitive distortion including self-worth [7] and to negative emotional memories consolidation. Studies have demonstrated that there is a failure of sleep dependent emotional brain processing in REM sleep in depression which seems to support the development of clinical depression [8].
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