Significance of protection to integrity of air passage in therapy to gravis type viral pneumonia

Abstract

Objective To probe significance of protection to integrity of air passage in therapy to gravis type viral pneumonia complicating acute respiratory distress syndrome (ARDS). Methods 32 patients clinical diagnosed gravis type viral pneumonia complicating ARDS were cured by antiviral therapy,antibiotic,maintenance therapy and different oxygen therapies [16 patients cured by durative high flow oxygen therapy with face mask,seven patients cured by sequential therapy (they were cured by durative high flow oxygen therapy with face mask 48 hours,but their arterial partial pressure of oxygen and oxygenation index were aggravation than pretherapy,then they were given intubation mechanical ventilation),and nine patients cured by mechanical ventilation by tracheal intubation],then curative effect in three groups was obsrved.Results In 32 patients,five patients in the group of durative high flow oxygen therapy with face mask were dead,this group patients' arterial partial pressure of oxygen and oxygenation index post-treatment 48 hours,72 hours became better than pretherapy ( P ＜ 0.05).But some indexes had no statistical significance between post-treatment two hours and pretherapy.Four patients in the group of sequential therapy were dead,while six patients in the group of mechanical ventilation by tracheal intubation were dead.Their arterial partial pressure of oxygen and oxygenation index of post-treatment two hours in the group of sequential therapy and these of post-treatment 2,24,48,72 hours in the group of mechanical ventilation by tracheal intubation became better than pretherapy ( P ＜0.05).There was statistical significance between the difference of mortality in the group of durative high flow oxygen therapy with face mask and mechanical ventilation by tracheal intubation ( P ＜ 0.05).Conclusions High flow oxygen therapy can cure hypoxemia of gravis type viral pneumonia complicating ARDS,and maybe further reduce case fatality ratio than mechanical ventilation by tracheal intubation. Key words: Vaccinum Influenzae Vivums pneumonia; Grave pneumonia; Acute respiratory distress syndrome; Integrity of air passage