Significance of Plasma Osteopontin in Diagnosis of Hepatitis C Virus Related Hepatocellular Carcinoma

Abstract

Abstract Background Hepatocellular carcinoma (HCC) is a primary malignancy of the liver that occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Hepatocellular carcinoma is the sixth most common neoplasm and the third most frequent cause of cancer death. More than 700 000 cases of this malignant disease were diagnosed in 2008, with an age-adjusted worldwide incidence of 16 cases per 100 000 inhabitants. Hepatocellular carcinoma is the leading cause of death among patients with cirrhosis. Aim of the Work The aim of this study is to assess the diagnostic value of plasma OPN in the diagnosis of HCC among hepatitis C virus (HCV)-related LC. Patients and Methods Plasma levels of OPN will be measured in 20 healthy controls and 70 Egyptian patients with HCV-related LC. Patients will be divided into 2 groups: Group 1: 35 HCV patients with liver cirrhosis and HCC. Group 2: 35 HCV patients with liver cirrhosis without HCC. Result There was statistically significant difference between the studied groups as regard sex. There was highly significant difference between the studied groups as regard CBC. As regard HB there was highly significant difference between (control and group 1) and (control and group 2) and significant difference between (group 1 and group 2). As regard INR there was highly significant difference between (control and group 1) and (control and group 2). As regard Platelets there was highly significant difference between (control and group 1) and (control and group 2) and significant difference between (group 1 and group 2). There was highly significant difference between the studied groups as regard Albumin and Total Bilirubin and significant difference as regard ALT and ALP. There was no significant difference between the studied groups as regard Child–Pugh class. There was highly significant difference between the studied groups as regard OPN. Using roc curve, it was shown that OPN level can be used to discriminate between patients and controls at a cutoff level of > 146.9, with 60% sensitivity, 97.14% specificity, 95.5% PPV and 70.8% NPV. Conclusion OPN level can be used to discriminate between patients and controls at a cutoff level of > 146.9, with 60% sensitivity, 97.14% specificity, 95.5% PPV and 70.8% NPV.