Abstract

Objective To investigate the significance of osteopontin (OPN), interleukin-10 (IL-10), interleukin-35 (IL-35) and transforming growth factor-β (TGF-β) in treatment of idiopathic thrombocytopenic purpura (ITP) by glucocorticoid. Methods Sixty patients with ITP were enrolled in this study as observation group, 30 healthy patients were selected as control group. Patients in observation group were treated with glucocorticoid for 4 weeks. The levels of OPN, IL-10, IL-35, TGF-β in blood and bone marrow were detected and compared between control group and observation group before and after treatment. Results Compared with control group, the levels of OPN, IL-35 and TGF-β in blood and bone marrow of observation group were significantly higher, and IL-10 level was significantly lower (P<0.05). In observation group, the levels of OPN, IL-35 and TGF-β after treatment were significantly lower than that before treatment and the postoperative IL-10 levels was significantly higher that that before treatment (P<0.05). Conclusions OPN, IL-10, IL-35 and TGF-β have certain significance in the treatment of ITP by glucocorticoid. Glucocorticoid has a certain clinical efficacy in the treatment of ITP. Key words: Idiopathic thrombocytopenic purpura; Osteopontin; Interleukin-10; Interleukin-35; Transforming growth factor-β

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