Significance of malignant peritoneal cytology on survival of women with uterine sarcoma

Abstract

Objectives: To examine the association between malignant peritoneal cytology and survival in women with uterine sarcoma. Methods: This is a retrospective observational study querying the National Cancer Institute's Surveillance, Epidemiology, and End Result Program. Uterine sarcoma cases diagnosed from 2010 to 2016 with known peritoneal cytology results were examined. Propensity score inverse probability of treatment weighting was fitted to balance the measured covariates, and overall survival (OS) was compared between malignant and negative cytology cases. Results: A total of 1,481 uterine sarcomas were examined, and malignant peritoneal cytology was seen in 146 (9.9%) cases. Women who had T3 disease and distant metastases had the highest incidence of malignant peritoneal cytology (43.1%). In multivariable analysis, higher T stage, nodal involvement, distant metastasis, poorer tumor differentiation, and rhabdomyosarcoma/endometrial stromal sarcoma were significantly associated with an increased risk of malignant peritoneal cytology (all, P Download : Download high-res image (80KB) Download : Download full-size image Conclusions: Our study suggests that malignant peritoneal cytology may be a prognostic factor for increased mortality in uterine sarcoma, particularly in uterine leiomyosarcoma.