Abstract
Trauma-induced suppression of cellular immune function likely contributes to sepsis, multiple organ dysfunction syndrome, and death. Recently, by controlling immune and inflammatory responses, macrophage migration inhibitory factor (MIF) is thought to play an important role in the pathophysiology of septic shock and chronic inflammatory diseases. However, the role of MIF in trauma-like conditions is unknown. Generally, hypertonic saline (HTS) has been known for its anti-inflammatory effect. Therefore, the experiments were conducted to evaluate MIF after stimulating lipopolysaccharide (LPS), which induced infection, or fMLP, which induced trauma-like condition, either in the presence or absence of HTS in macrophage or polymorphonuclear leukocyte (PMN), in response to early phase injury.
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