Significance of HPV test combined with colposcopy in distribution of patients with cervical atypical squamous cells

Abstract

Objective To investigate the value of human papillomavirus (HPV) test combined with colposcopy in the diagnosis of distribution of patients with cervical atypical squamous cells (ASCUS). Methods A total of 214 patients with ASCUS who had cervical cytology examinations from January 2015 to January 2019 in Datong Integrated Hospital of Traditional Chinese and Western Medicine were selected. All patients underwent cervical cytology, high risk human papilloma virus(HR-HPV), colposcope and biopsy pathology examination, and the results were analyzed. Results The results of histopathological examination in 214 patients with ASCUS were as follows: 135 cases of inflammation, 24 cases of condyloma, 17 cases of cervical intraepithelial neoplasia (CIN Ⅰ), 20 cases of CIN Ⅱ, 15 cases of CIN Ⅲ, 1 case of invasive cancer, 1 case of adenocarcinoma, 1 case with high degree of glandular epithelium abnormality and 0 case with low degree of glandular epithelium abnormality. Among the 214 patients with ASCUS, 173 cases were positive and 41 cases were negative by HR-HPV. The number of HR-HPV positive cases in patients with inflammation, genital warts, CINI, CINII, CINIII, invasive carcinoma, adenocarcinoma, and high glandular epithelial abnormalities were 120 cases, 10 cases, 14 cases, 9 cases, 10 cases, 0 case, 0 case, 1 case. The number of HR-HPV negative cases in patients with inflammation, genital warts, CIN I, CIN II, CIN III, invasive carcinoma, adenocarcinoma, and high glandular epithelial abnormalities were 15 cases, 4 cases, 3 cases, 11 cases, 5 cases, 1 case, 1 case, 0 case. Histopathological examination results showed that there were a total of 141 cases of high CIN, 3 points and above in patients with inflammation, genital warts and CINI. There were 27 cases of high CIN in CIN II and CIN III.There were 2 cases of high CIN in invasive carcinoma, adenocarcinoma, high glandular epithelial abnormality, and low grade glandular epithelial abnormalities. The difference between the two was significant (Z=-24.621, P<0.05). Conclusions HPV combined with colposcopy can reduce ASCUS false positive, which is beneficial for clinical of hig-risk ASCUS patients. Key words: Human papillomavirus; Cervical cytology; Atypical squamous cells; Colposcopy