Abstract
Aim: We measured Golgi protein73 (GP73), alpha-fetoprotein (AFP), and vascular endothelial growth factor (VEGF) expression in primary hepatic cancer (PHC) and assessed their clinical significance. Methods: Forty-five PHC and tumor-adjacent specimens and 14 normal liver specimens were examined. GP73, AFP, and VEGF expression was measured via immunohistochemistry and a correlation of protein expression with clinical pathology of PHC was suggested. Results: GP73, AFP, and VEGF expression was significantly higher in PHC and tumor-adjacent tissue compared to tumor-adjacent tissue (0.143 ± 0.018 vs. 0.124 ± 0.027, 0.116 ± 0.026 vs. 0.098 ± 0.014, and 0.126 ± 0.027 vs. 0.092 ± 0.016, respectively; all p 0.088 ± 0.029, 0.098 ± 0.014 vs. 0.073 ± 0.011, and 0.092 ± 0.016 vs. 0.076 ± 0.018, respectively; all p p < 0.05). Conclusion: GP73 is highly expressed in PHC and may be a diagnostic marker. Combined detection of GP73, AFP, and VEGF is helpful for diagnosis of PHC.
Highlights
Primary hepatic cancer (PHC) is a malignant tumor with poor prognosis and rapid progression
Golgi protein73 (GP73) expression measurements in liver cancer, tissue adjacent to cancer tissue and normal liver tissue reveal that GP73 is mainly expressed in the cytoplasm of cancers (Figure 1(A)), as indicated by yellow or yellow-brown particulate staining
Expression in tissue adjacent to carcinoma is visible, but weak compared to carcinoma tissue (Figure 1(B)); Normal liver rarely expresses GP73
Summary
Primary hepatic cancer (PHC) is a malignant tumor with poor prognosis and rapid progression. Using AFP is not ideal method for early PHC diagnosis; a positive serum AFP only occurs 56% of the time. New tumor markers have been discovered via proteomic techniques and GP73 has been identified to be a novel tumor marker that is related to viral hepatitis and PHC. Research suggests that GP73 expression sensitivity in PHC tissue exceeds AFP and because of this, GP73 may serve as a new oncology index for diagnosing PHC [1]. We assess the value of GP73 for diagnosing PHC by measuring this protein in cancer and normal tissue
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