Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma

Jing Jing Han,De Rong Xie,Gong Fa Wu,Li Li Wang,Ye Qing Liu,Qing Sun,Zhi Quan Huang,Hai Gang Li,Yan Xian Chen,Ying Wei

doi:10.1155/2013/380193

Abstract

Aim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens. The association of GPX1 and CDX2 with patient's clinicopathological features and Ki67 positive rate was analyzed statistically. Results. In 172 cases of GAC, the expression of GPX1 was weaker than that in adjacent normal mucosa, and the expression of CDX2 was higher than that in adjacent normal mucosa. High expression GPX1 strong-expression was associated with differentiation, Lauren type, WHO type and extensive lymph node metastasis of GAC. High expression of CDX2 was associated with differentiation, Lauren type, WHO type, extensive lymph node metastasis, and TNM of GAC. Survival curves showed that expressions of GPX1 and CDX2 were factors of good outcome (P = .03 and .02, resp.). According to multivariate analysis, only lymph node metastasis, TNM stage, and CDX2 expression were independently associated with survival. In addition, a strong association of GPX1 expression was noted with Ki67 and CDX2. Conclusions. The expression of GPX1 and CDX2 may play a role in the carcinogenesis, differentiation, and progression of GAC, and CDX2 may be an independent prognostic factor.

Highlights

Gastric adenocarcinoma (GAC) is one of the most common fatal malignancies in the world
We immunohistochemically examined the expressions of glutathione peroxidase 1 (GPX1), CDX2, and Ki67 in 172 samples of human gastric adenocarcinomas
The expression GPX1 was not associated with age, sex, or tumor node metastasis (TNM) stage (P > .05) (Table 1)

Summary

Introduction

Gastric adenocarcinoma (GAC) is one of the most common fatal malignancies in the world. Patients with gastric cancer that is limited to the mucosa and submucosa have an excellent prognosis, with a 5-year survival rate of over 90%. Therapeutic decisions are based on clinicopathological parameters, including age, tumor node metastasis (TNM) stage, and histological grade. Useful, these factors often fail to differentiate more aggressive tumor types from less aggressive tumor types [5]. As GAC is a markedly heterogeneous disease with respect to histological features and biological characteristics especially in the advanced stages, previous studies have shown that its biological behavior and prognosis could be significantly different among the patients with the same stage, histological type, or differentiation grade

Methods

Results

Conclusion