Abstract

By means of GeXP (gene expression profiling),quantitative analysis was carried out to investigate the gene expression on pheochromocytoma/paraganglioma specimens.30 samples were collectcd from 16 patients with benign pheochromocytoma and 14 with malignant pheochromocytoma/paraganglioma.Our results suggest that lower expressions of genes encoding peptide processing factors including QPCT,HSPA4L,RNF6 and RNF128 in pheochromocytomas/paragangliomas may point to a malignant diagnosis. Key words: Pheochromocytoma; Differential diagnosis; Gene expression profiling; Gene expression

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