Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)

Abstract

Background: IMP3, PPARG and PD-L1 have been implicated in tumorigenesis and progression in many cancers, but their significance in urothelial carcinoma remains unclear. Aim: The aim of this study is to assess the possible significance of IMP3, PPARG and PD-L1 in urothelial bladder carcinoma and determine the relation between their expressions and different clinicopathological (tumor size, grade, histological variant, muscle invasion, lymphovascular invasion and pathologic T stage) and molecular variables. Methods: This study aimed to evaluate immunohistochemical expression of IMP3, PPARG and PD-L1 and correlate them with clinicopathological and molecular variables. Results: IMP3 was significantly correlated to muscle invasion (P 0.05).Conclusions: IMP3 may be used as a prognostic marker. PPARG may be used to identify the luminal molecular subtype. PD-L1 may be used as a prognostic marker for tumor aggressiveness, so it may be used in immunotherapy.