Abstract
AbstractAdverse clinical reactions (predominantly skin rashes) were seen in 14 of 50 patients receiving gold therapy for rheumatoid arthritis. In 11 of the 14 eosinophilia either accompanied or preceded the reaction. A further 9 patients who received gold developed eosinophilia alone. IgE levels were increased in 17 of the 20 patients with eosinophilia but were normal in 24 of 27 patients who received gold without apparent adverse effects. In only 1 patient on gold was a skin rash not accompanied by either eosinophilia or a raised IgE level. All eosinophil counts and IgE levels fell to normal after therapy was discontinued. It is suggested that eosinophilia may be the most common side effect of gold therapy and provides a useful guide for monitoring patients receiving gold salts. The strong association with raised IgE levels suggests that type 1 hypersensitivity may be the mechanism of these reactions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
