Abstract

N-Acetyl- β-D-glucosaminidase (NAG) activity and β 2-microglobulin ( β 2-m) concentration were measured in the urine of inhabitants of a cadmium-polluted area (Cd), including patients with, or suspected, “itai-itai” disease and control subjects. Urinary NAG activity increased with increasing β 2-m concentration up to about 100 U/g creatinine; above this value the NAG activity did not increase with increasing β 2-m concentration. Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and β 2-m into urine are thought to be different.

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