Significance of different types of samples for the laboratory detection of yellow fever

Abstract

Objective To investigate the significance of different type samples for the laboratory detection of yellow fever. Methods Different types of samples were collected at different time from 5 yellow fever cases, and the yellow fever virus RNA was detected by real-time PCR. Results For the 5 cases among the samples collected in ≥6 days from the onset, only the serum sample from 1 patient was positive and the urine samples from the other 4 patients were positive. Conclusions In the early phase of yellow fever, the viral RNA detection is a fast and sensitive laboratory test method, and serum is the appropriate clinic sample for the viral RNA detection. With the lapse of time, urine becomes the appropriate clinic sample for the viral RNA detection. Key words: Yellow fever; Laboratory detection; Viral RNA; Sample