Abstract
BackgroundCommon variants on human chromosome 8q24, rs1447295 (C/A) and rs6983267 (T/G), have been recently linked to the prevalence of prostate cancer in European and American populations. Here, we evaluated whether the single-nucleotide polymorphisms rs1447295 and rs6983267 were associated with the risk of sporadic prostate cancer as well as latent prostate cancer in a native Japanese population.ResultsWe analyzed genomic DNA samples from 391 sporadic prostate cancer patients, 323 controls who had died from causes unrelated to cancer and 112 Japanese men who were diagnosed as having latent prostate cancer based on autopsy results. The polymorphisms were determined by allelic discrimination using a fluorescent-based TaqMan assay. The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27). No significant difference between these two polymorphisms and the risk of latent prostate cancer was observed in the present Japanese population.ConclusionKnown variants on human chromosome 8q24 may be risk factors for sporadic prostate cancer in native Japanese men.
Highlights
Common variants on human chromosome 8q24, rs1447295 (C/A) and rs6983267 (T/G), have been recently linked to the prevalence of prostate cancer in European and American populations
The genotype distributions for each SNP were consistent with Hardy-Weinberg equilibrium (HWE)
We confirmed that the rs1447295 and rs6983267 polymorphisms were significantly associated with the risk of sporadic prostate cancer in native Japanese men
Summary
Common variants on human chromosome 8q24, rs1447295 (C/A) and rs6983267 (T/G), have been recently linked to the prevalence of prostate cancer in European and American populations. The prevalence of the rs1447295 polymorphism associated with prostate cancer was investigated in a population of Indian-born Asian Indians who had emigrated from India and were living in the United States [14]. In 2007, Haiman et al [8] and Yeager et al [9] showed a strong association between rs6983267 and the risk of prostate cancer Their investigations included African Americans, Latino Americans, European Americans, Japanese Americans, native Hawaiians, Australians, Swedish, Icelanders, and the British, but not native Japanese or other East Asian men. We felt that it was important to replicate the study in a population of native Japanese subjects to better understand the disparities in prostate cancer risk among different ethnicities
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