Abstract
Nutritional and metabolic processes involve numerous pathways. It is highly significant to clarify the presence and function of signaling molecules involved in each pathway. A Cbl-interacting protein of 85 kDa (CIN85) belongs to a family of ubiquitously expressed adaptor/scaffold proteins. CIN85 is a multiadaptor protein implicated in the regulation of receptor endocytosis, cell division, and the cellular cytoskeleton. Mice deficient in brain-specific CIN85 expression shows aberrant dopamine signaling; insufficient complex formation of endophilins with D2 dopamine receptors (D2DRs) in the striatum, an important center for the coordination of animal behavior and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. As a result, CIN85-deficient mice exhibit the hyperactive phenotype. Here, we show other phenotypes of CIN85 deficient-mice; low levels of bone mineral density and blood glucose. From a perspective of nutritional research, the analysis of CIN85 and its deficiency in mice may lead to new developments in nutritional study.
Highlights
Adaptor proteins are noncatalytic polypeptides that contain one or more domains that can bind to other proteins or nonprotein ligand molecules [1]
J Nutri Bio, 1(1): 1-06 (2015) doi: Previously, we reported a novel in vivo function of Cbl-interacting protein of 85 kDa (CIN85) in the regulation of postsynaptic dopamine receptor endocytosis in striatal neurons [6]
As a molecular explanation of this phenotype, we concluded that the absence of striatal CIN85 causes insufficient formation of complexes of endophilins with dopamine receptors in the striatum and suppressed dopamine receptor endocytosis in striatal neurons in response to dopamine stimulation
Summary
Adaptor proteins are noncatalytic polypeptides that contain one or more domains that can bind to other proteins or nonprotein ligand molecules [1]. These molecules are essential for intracellular signal transduction involved in the regulation of metabolic activity, endocrine action, neuronal function, and cell growth. J Nutri Bio, 1(1): 1-06 (2015) doi: Previously, we reported a novel in vivo function of CIN85 in the regulation of postsynaptic dopamine receptor endocytosis in striatal neurons [6].
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